Cycloalkyl inhibitors of protein farnesyltransferase

Details Cycloalkyl inhibitors of protein farnesyltransferase Cycloalkyl inhibitors of protein farnesyltransferase

C - Chemistry, Metallurgy

07

K

C07K 5/078 (2006.01) A61K 38/05 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2264207

Novel inhibitors of protein farnesyltransferase enzymes are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer, restenosis, atherosclerosis, psoriasis, and endometriosis.

L'invention concerne des nouveaux inhibiteurs d'enzymes protéine farnésyltransférase ainsi que leurs procédés de préparation et de compositions pharmaceutiques les contenant, lesquels sont utiles dans la lutte contre des maladies prolifératives tissulaires, notamment le cancer, la resténose, l'athérosclérose, le psoriasis et l'endométriose.

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