Cycloalkyl keto piperidine tachykinin receptor antagonists

Details Cycloalkyl keto piperidine tachykinin receptor antagonists Cycloalkyl keto piperidine tachykinin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 211/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 411/00 (2006.01) C07D 413/00 (2006.01) C07D 417/00 (2006.01) C07D 419/00 (2006.01) C07D 421/00 (2006.01)

Patent

CA 2587195

The present invention is directed to certain piperidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

La présente invention concerne des composés de pipéridine utiles comme antagonistes des récepteurs de la neurokinine 1 (NK-1) et comme inhibiteurs de la tachykinine, et notamment de la substance P. L'invention concerne également des préparations pharmaceutiques comprenant ces composés comme ingrédients actifs ainsi que l'utilisation de ces composés et de leurs préparations dans le traitement de certaines affections, telles que le vomissement, l'incontinence urinaire, la dépression et l'anxiété.

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