C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/08 (2006.01) A61K 31/451 (2006.01) A61K 31/454 (2006.01) A61K 31/506 (2006.01) C07D 211/46 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2586972
The present invention is directed to certain piperidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
L'invention concerne certains composés pipéridine utiles en tant qu'antagonistes du récepteur de la neurokinine 1 (NK-1), et des inhibiteurs de tachykinine et en particulier de substance P. L'invention concerne également des formulations pharmaceutiques comprenant ces composés utilisés en tant qu'ingrédients actifs et l'utilisation desdits composés et de leurs formulations dans le traitement de certains troubles, notamment les vomissements, l'incontinence urinaire, la dépression, et l'anxiété.
Devita Robert J.
Eid Ronsar
Mills Sander G.
Young Jonathan R.
Merck & Co. Inc
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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