Cycloalkyl-substituted glutaramide antihypertensive agents

Details Cycloalkyl-substituted glutaramide antihypertensive agents Cycloalkyl-substituted glutaramide antihypertensive agents

C - Chemistry, Metallurgy

07

C

C07C 237/24 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/33 (2006.01) C07C 233/63 (2006.01) C07C 235/40 (2006.01) C07C 237/36 (2006.01) C07C 247/12 (2006.01) C07C 271/22 (2006.01) C07C 271/66 (2006.01) C07C 273/18 (2006.01) C07C 317/44 (2006.01) C07C 317/48 (2006.01) C07C 323/60 (2006.01) C07C 323/67 (2006.01) C07D 211/44 (2006.01) C07D 211/46 (2006.01) C07D 211/58 (2006.01) C07D 211/74 (2006.01) C07D 233/61 (2006.01) C07D 295/145 (2006.01) C07D 295/155 (2006.01) C07D 309/12 (2006.01) C07D

Patent

CA 2073450

2073450 9113054 PCTABS00007 Compounds of formula (I), wherein A completes a 5 or 6 membered carbocyclic ring which may be saturated or monounsaturated; Y is an alkylene group of from 1 to 9 carbon atoms; R1 is H or (C1-C4)alkyl; R and R4 are H, (C1-C6)alkyl, (C3-C7)cycloalkyl, benzyl, or an alternative biolabile ester-forming group; R2 is defined to include a range of substituent groups including (C1-C6)alkoxy, (C1-C4)alkoxy-(C1-C6)alkoxy and various substituted-alkyl, amino, substituted amino, aryl and heterocyclyl substituents linked directly or by O, S(O)n, NR6, CO or CONR6 wherein R6 is H, (C1-C4)alkyl or aryl(C1-C4)alkyl and n is 0, 1 or 2; R3 is a group of formula (II), wherein R13 is H, halo, 4-OH, 4-(C1-C6 alkoxy), 4-(C3-C7 cycloalkoxy), 4-(C2-C6 alkenyloxy), 4-[(C1-C6 alkoxy)carbonyloxy], 4-[(C3-C7 cycloalkyloxy)carbonyloxy], or 3-(C1-C4 alkyl)SO2NH-; and R14 is H, (C1-C4)alkyl, (C1-C4)alkoxy, (C2-C6)alkanoyl or halo; or R3 is a group of formulae (III) or (IV), wherein said groups may optionally be substituted in the fused benzene ring by (C1-C4)alkyl, (C1-C4)alkoxy, OH, halo or CF3; or are atriopeptidase inhibitors or utility in the treatment of hypertension and heart failure.

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