Cycloalkyl-substituted glutaramide diuretic agents

Details Cycloalkyl-substituted glutaramide diuretic agents Cycloalkyl-substituted glutaramide diuretic agents

C - Chemistry, Metallurgy

07

C

C07C 235/40 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) A61K 31/27 (2006.01) A61K 31/33 (2006.01) C07C 237/24 (2006.01) C07C 271/12 (2006.01) C07C 271/22 (2006.01) C07C 279/14 (2006.01) C07C 311/06 (2006.01) C07D 207/14 (2006.01) C07D 295/15 (2006.01) C07D 317/40 (2006.01)

Patent

CA 2067197

2067197 9107378 PCTABS00005 Compounds of formula (I), wherein A completes a 4 to 7 membered carbocyclic ring which may be saturated or mono-unsaturated and which may optionally be fused to a further saturated or unsaturated 5 or 6 membered carbocyclic ring; B is (CH2)m wherein m is an integer of from 1 to 3; each of R and R4 is independently H, C1-C6 alkyl, benzyl or an alternative biolabile ester-forming group; R1 is H or C1-C4 alkyl; R2 is C1-C6 alkyl substituted by C1-C4 alkoxy, aryl or aryloxy and R5 is defined to include a range of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, and substituted alkyl groups including in particular methoxyethyl, 2-methoxyethoxymethyl, N2-substituted-S-lysylaminomethyl, R-alanylaminomethyl and (2-amino-2-methyl-propanoyl) aminomethyl; are atriopeptidase inhibitors of utility in the treatment of hypertension, heart failure, renal insufficiency and other disorders.

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