Cycloalkylamines as monoamine reuptake inhibitors

Details Cycloalkylamines as monoamine reuptake inhibitors Cycloalkylamines as monoamine reuptake inhibitors

C - Chemistry, Metallurgy

07

C

C07C 211/27 (2006.01) A61K 31/13 (2006.01) A61K 31/135 (2006.01) A61K 31/27 (2006.01) A61K 31/335 (2006.01) A61K 31/381 (2006.01) A61P 25/00 (2006.01) A61P 25/24 (2006.01) C07C 215/44 (2006.01) C07C 255/46 (2006.01) C07D 277/28 (2006.01) C07D 307/36 (2006.01) C07D 333/24 (2006.01)

Patent

CA 2636324

The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

L'invention concerne de nouveaux dérivés de cyclohéxylamine et leur utilisation dans le traitement et/ou la prévention des troubles du système nerveux central (SNC), tels que la dépression, l'anxiété, la schizophrénie et les troubles du sommeil, ainsi que des procédés de synthèse de ceux-ci. L'invention concerne également des compositions pharmaceutiques contenant les composés de l'invention, ainsi que des procédés d'inhibition du recaptage des monoamines endogènes, telles que la dopamine, la sérotonine et la norépinéphrine de la fente synaptique, et des procédés de modulation d'un ou de plusieurs transporteurs de monoamines.

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