C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/757 (2006.01) A61K 31/13 (2006.01) A61K 31/164 (2006.01) A61K 31/215 (2006.01) A61P 3/08 (2006.01) C07C 69/74 (2006.01) C07C 69/753 (2006.01) C07C 217/08 (2006.01) C07C 233/63 (2006.01)
Patent
CA 2480557
The invention provides novel compounds of the Formula (I) that stimulate rates of glucose oxidation in myocardial cells wherein W, Cyc, p, , X, Z, R, K-, R, R1, R2, R3,R4, I and n are as defined for Formula (I) herein. The invention also relates to pharmaceutical compositions comprising compounds capable of stimulation of glucose Oxidation, methods for increasing glucose oxidation rates in myocardial cells, and methods of treatment of myocardial ischemia.
La présente invention concerne de nouveaux composés de formule (I) qui stimulent les taux d'oxydation du glucose dans des cellules myocardiques, W, Cyc, p, Y, X, Z, R, R?1¿, R?2¿, R?3¿, R?4¿, i et n étant tels que définis dans la formule (I) susmentionnée. L'invention concerne également des compositions pharmaceutiques comprenant des composés à même de stimuler l'oxydation du glucose, des méthodes permettant d'augmenter les taux d'oxydation du glucose dans des cellules myocardiques ainsi que des méthodes de traitement de l'ischémie myocardique.
Dyck Jason Ronald
Lopaschuk Gary David
Vederas John Christopher
Mbm Intellectual Property Law Llp
The Governors Of The University Of Alberta
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