Cycloalkylcarboxyl derivatives that stimulate glucose...

Details Cycloalkylcarboxyl derivatives that stimulate glucose... Cycloalkylcarboxyl derivatives that stimulate glucose...

C - Chemistry, Metallurgy

07

C

C07C 69/74 (2006.01) A61K 31/185 (2006.01) A61K 31/21 (2006.01) A61K 31/34 (2006.01) C07C 321/22 (2006.01) C07C 323/51 (2006.01) C07C 327/24 (2006.01) C07D 307/54 (2006.01)

Patent

CA 2598595

The invention provides novel compounds of the Formula (I) that stimulate rates of glucose oxidation in myocardial cells: Formula (I) wherein W, Cyc, p, Y, X, Z, R, R1, R2, R3, R4, I, m and n are as defined for Formula (I) herein. The invention also relates to pharmaceutical compositions comprising compounds capable of stimulation of glucose oxidation, methods for increasing glucose oxidation rates in myocardial cells, and methods of treatment of myocardial ischemia.

L'invention concerne de nouveaux composés de formule (I) stimulant les vitesses d'oxydation de glucose dans des cellules myocardiques. Dans la formule (I), W, Cyc, p, Y, X, Z, R, R1, R2, R3, R4, I, m et n sont définis dans la description. L'invention concerne également des compositions pharmaceutiques comprenant des composés pouvant stimuler l'oxydation de glucose, des méthodes pour augmenter les vitesses d'oxydation du glucose dans des cellules myocardiques, et des méthodes de traitement de l'ischémie myocardique.

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