C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/233, 260/305
C07D 233/61 (2006.01) A61K 31/41 (2006.01) C07D 249/04 (2006.01) C07D 249/08 (2006.01) C07D 333/38 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2022682
The disclosure relates to cycloalkylene azoles of general Formula I Image (I), wherein Image is a carbocyclic or carbopolycyclic group optionally carrying at least one alkyl substituent, X is the grouping Image , an oxygen or sulfur atom, and Y and Z, independently of each other, are Image , or a nitrogen atom, as well as their pharmaceutically compatible addition salts with acids as well as processes for production thereof. The compounds possess strongly aromatase- inhibiting activity and are uitable for the preparation of medicinal agents. Methods for treating estrogen induced or stimulated tumors, male infertility, and impending cardiac infarction with these compounds are also provided as well as methods for inhbiiting female fertility.
Bohlmann Rolf
Henderson David
Nishino Yukishige
Schneider Martin
Strehlke Peter
Bohlmann Rolf
Henderson David
Marks & Clerk
Nishino Yukishige
Schering Aktiengesellschaft
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