Cycloalkylfused [g]-indole compounds as spla2-inhibitors in...

C - Chemistry – Metallurgy – 07 – D

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C07D 209/42 (2006.01) A61K 31/40 (2006.01) C07D 209/12 (2006.01) C07D 209/14 (2006.01) C07D 209/22 (2006.01) C07D 209/30 (2006.01) C07D 209/60 (2006.01) C07D 209/70 (2006.01) C07D 409/10 (2006.01)

Patent

CA 2430808

A class of cycloalkylfused (g) indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.

L'invention concerne une nouvelle classe de composés indoles réunis par fusion à des cycloalkyles, ainsi que l'utilisation de ces composés pour inhiber la libération d'acides gras par la sPLA2, pour le traitement de maladies inflammatoires, telles que le choc septique.

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