Cycloalkylthiazole derivatives

Details Cycloalkylthiazole derivatives Cycloalkylthiazole derivatives

C - Chemistry, Metallurgy

07

D

167/234, 260/310

C07D 277/30 (2006.01) A61K 31/425 (2006.01) C07D 277/28 (2006.01)

Patent

CA 1333906

The compounds of the general formula Image wherein R is hydrogen or lower alkyl, R1, R2, R3 and R4, independently, are hydrogen, lower alkyl, lower alkenyl, C3 6-cycloalkyl or a phenyl group, which is unsubstituted or substituted by up to 3 substituents independently selected from lower alkyl, lower alkoxy or halogen, or R1 and R2 taken together with the carbon atom, to which they are attached are a C2 5-alkylene group, which is unsubstituted or substituted by lower alkyl, and n is an integer of from 0 to 3, and, when R1 is different from R2 and/or R3 is different from R4, enantiomers, diastereomers and racemates thereof and, when R is hydrogen, salts thereof with pharmaceutically acceptable bases are useful as bronchopulmonary agents, for example, in the relief of asthma and allergic reactions.

605532

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