C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/04 (2006.01) A61K 31/395 (2006.01) C07D 209/46 (2006.01) C07D 217/24 (2006.01) C07D 223/16 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2192460
The present invention relates to novel cyclobut-3-ene-1,2-dione-3-yl substituted benzopyrans, indanes and tetrahydronaphthalenones having smooth muscle relaxant activity, pharmaceutical compositions containing them, and to their use in the treatment of diseases and disorders involving excessive smooth muscle contractions in the cardiovascular system, urinary tract, pulmonary system, or gastrointestinal tract such as hypertension, periferal vascular disease, congestive heart failure, urinary incontinence, irritable bowel syndrome, asthma, and hair loss. The compounds of this invention are represented by Formula (I), wherein variable substituents R1-R7 are as defined in the summary of the invention; a and b together form an -O- linkage, C=O, or a direct bond; and n = 1-3.
La présente invention se rapporte à de nouveaux benzopyranes substitués par cyclobut-3-ène-1,2-dione-3-yle, à des indanes et des tétrahydronaphtalénones agissant comme dépresseurs sur les fibres lisses, à des compositions pharmaceutiques les contenant, et à leur utilisation dans le traitement de maladies et troubles tels que les contractions excessives des muscles lisses dans le système cardio-vasculaire, les voies urinaires, le système pulmonaire ou les voies gastro-intestinales et comme l'hypertension, les maladies vasculaires périphériques, l'insuffisance cardiaque congestive, l'incontinence urinaire, la colopathie fonctionnelle, l'asthme et la chute des cheveux. Les composés de cette invention sont représentés par la formule (I) dans laquelle les substituants variables R¿1?-R¿7? sont tels que définis dans le résumé de l'invention; a et b réunis forment une liaison -O-, C=O ou une liaison directe; et n = 1-3.
Dollings Paul Jeffrey
Kinney William Alvin
Soll Richard Michael
American Home Products Corporation
Ridout & Maybee Llp
LandOfFree
Cyclobut-3-ene-1,2-dione derivatives as smooth muscle relaxants does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyclobut-3-ene-1,2-dione derivatives as smooth muscle relaxants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclobut-3-ene-1,2-dione derivatives as smooth muscle relaxants will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1508347