C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/6561 (2006.01) A61K 31/52 (2006.01) A61K 31/675 (2006.01) C07D 473/00 (2006.01) C07F 9/6558 (2006.01)
Patent
CA 2043099
ABSTRACT OF THE DISCLOSURE This invention relates to cyclobutane derivatives represented by the following general formula (1) and physiologically acceptable salts thereof: Image (1) wherein B represents a nucleic acid base derivative, R1 and R2 independently represent hydrogen atom, dialkyl- aminoacyl group, 1,4-dihydro-1-methylnicotinoyl group or substituted phosphoric acid group, provided that either one of R1 and R2 is a group other than hydrogen atom. The compounds of this invention exhibit a high oral absorbability and are metabolized in vivo into the compounds of formula (1a). Accordingly, the compounds of this invention are expectedly useful as antiviral agent.
Akaba Hiroshi
Ichikawa Yuh-Ichiro
Kato Sayuri
Matsubara Kenichi
Nagahata Takemitsu
Marks & Clerk
Nippon Kayaku Kabushiki Kaisha
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