Cyclobutene derivatives, their preparation and their...

Details Cyclobutene derivatives, their preparation and their... Cyclobutene derivatives, their preparation and their...

C - Chemistry, Metallurgy

07

C

C07C 225/20 (2006.01) A61K 31/135 (2006.01) A61K 31/38 (2006.01) A61K 31/382 (2006.01) A61K 31/44 (2006.01) A61K 31/4409 (2006.01) A61P 3/00 (2006.01) A61P 7/00 (2006.01) C07C 229/16 (2006.01) C07C 233/40 (2006.01) C07C 233/44 (2006.01) C07C 233/78 (2006.01) C07C 239/16 (2006.01) C07C 251/48 (2006.01) C07C 309/14 (2006.01) C07C 323/30 (2006.01) C07C 323/31 (2006.01) C07C 323/32 (2006.01) C07C 325/02 (2006.01) C07D 207/335 (2006.01) C07D 209/14 (2006.01) C07D 213/38 (2006.01) C07D 213/50 (2006.01) C07D 233/6

Patent

CA 2312203

Compounds of formula (I): (see formula I) {in which: R1 and R2 each represents a variety of organic groups; R3 and R4 each represents hydrogen or a variety of organic groups; A represents a group of formula (A-1): (see formula II) [in which: R5 represents hydrogen, hydroxy or alkyl, R6 represents hydroxy, alkoxy, alkylthio or an amine residue, X and Y each represents oxygen or sulphur, and Z represents a direct single bond between the nitrogen atom shown and the benzene ring shown in formula (I), or an alkylene group], G represents a single bond, alkylene or substituted alkylene; the broken line represents a single or double bond; when the broken line represents a double bond, D represents a carbon atom; and E represents an =N-O- group; when the broken line represents a single bond, D represents a CH group or a nitrogen atom, and E represents an oxygen atom, a sulphur atom, an -NH- group or a -CO- group}; and pharmaceutically acceptable salts, esters or other derivatives thereof have the ability to inhibit an ileal bile transporter and so may be used to treat or prevent hypercholesterolaemia.

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