Cyclobutyl sulfones as notch sparing gamma secretase inhibitors

Details Cyclobutyl sulfones as notch sparing gamma secretase inhibitors Cyclobutyl sulfones as notch sparing gamma secretase inhibitors

C - Chemistry, Metallurgy

07

C

C07C 317/30 (2006.01) A61K 31/18 (2006.01) A61K 31/277 (2006.01) A61P 25/28 (2006.01) C07C 317/44 (2006.01) C07C 317/48 (2006.01)

Patent

CA 2721910

The invention encompasses a novel class of cyclobutyl sulfone derivatives which inhibit the processing of APP by the putative .gamma.-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included.

L'invention concerne une nouvelle classe de dérivés de cyclobutylsulfone qui inhibent la maturation de l'APP par la ?-secrétase putative, tout en épargnant la voie de signalisation Notch, et qui sont donc utiles dans le traitement ou la prévention de la maladie d'Alzheimer sans développement de problèmes gastro-intestinaux médiés par l'inhibition de Notch. Elle concerne également des compositions pharmaceutiques et des procédés d'utilisation.

Affiliated with

Also associated with

Rating

Cyclobutyl sulfones as notch sparing gamma secretase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclobutyl sulfones as notch sparing gamma secretase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclobutyl sulfones as notch sparing gamma secretase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1930282