A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/40 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 31/56 (2006.01) A61K 31/58 (2006.01) A61K 38/08 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2150554
Pharmaceutical compositions comprising a therapeutic agent, an effective stabilizing amount of carboxy-containing polymer and cyclodextrin, in an aqueous medium, wherein said cyclodextrin is selected from the group consisting of the hydroxypropyl, hydroxyethyl, glucosyl, maltosyl and maltotriosyl derivatives of ?, ? and ?-cyclodextrin, modified or unmodified; and methods for stabilizing and solubilizing a therapeutic agent in a pharmaceutial composition, comprising combining said therapeutic agent in an aqueous medium with an effective stabilizing amount of carboxy-containing polymer and an amount of cyclodextrin sufficient to at least partially solubilize said therapeutic agent, said cyclodextrin being selected from the group consisting of the hydroxypropyl, hydroxyethyl, glucosyl, maltosyl and maltotriosyl derivatives of ?, ? and ?-cyclodextrin, modified or unmodified.
Bowman Lyle M.
Tsao Sheng-Wan
Insite Vision Incorporated
Ridout & Maybee Llp
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