A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 47/40 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2497792
The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. In particular, the therapeutic/bioactive agents are covalently bound to the cyclodextrin-containing polymers. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distribution kits containing or relating to the polymeric compounds described herein.
L'invention concerne des compositions de composés polymères thérapeutiques contenant de la cyclodextrine, conçus comme support pour l'administration de petite molécule thérapeutique, ainsi que des compositions pharmaceutiques de ces composés. Ces polymères contenant de la cyclodextrine permettent d'améliorer la stabilité et la solubilité de médicaments et de réduire la toxicité de la petite molécule thérapeutique lorsqu'elle est utilisée in vivo. En outre, par sélection d'une variété de groupes liants et de ciblage de ligands, les polymères présentent des procédés de libération régulée des agents thérapeutiques. L'invention concerne aussi des méthodes de traitement de sujets à l'aide des compositions thérapeutiques décrites. Elle concerne enfin des procédés de gestion d'une affaire pharmaceutique comprenant fabrication, accords de licence ou de distribution de kits contenant ou se rapportant aux composés polymères décrits.
Cheng Jianjun
Davis Mark E.
Khin Kay T.
Borden Ladner Gervais Llp
Cerulean Pharma Inc.
Insert Therapeutics Inc.
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