Cyclodextrin clathrates of carbacyclin derivatives and their...

Details Cyclodextrin clathrates of carbacyclin derivatives and their... Cyclodextrin clathrates of carbacyclin derivatives and their...

C - Chemistry, Metallurgy

08

B

167/199, 167/205

C08B 37/16 (2006.01) A61K 31/715 (2006.01) A61K 47/48 (2006.01) C07C 405/00 (2006.01) C08B 37/00 (2006.01)

Patent

CA 1309087

ABSTRACT Cyclodextrin clathrates of carbacyclin analogs of general Formula I Image (I) wherein R1 is hydrogen, alkyl or alkenyl of up to 10 carbon atoms, A is a -CH2CH2-, trans-CH=C-, or -C?C-group, W is a free or functionally modified hydroxymethylene group or a free or functionally modified Image group, wherein the OH-group can be in the - or position, D is Image alkylene, or unsaturated alkylene each of which can optionally be substituted by fluorine atoms, m is 1, 2 or 3, E is a direct bond, a -C?C- group, or -CR4=CR5- group, wherein R4 is hydrogen or an alkyl group of 1-5 carbon atoms, and R5 is hydrogen or an alkyl group of 1-5 carbon atoms, and R5 is hydrogen, halogen, or an alkyl group of 1-5 carbon atoms, R2 is alkyl or alkenyl of up to 10 carbon atoms, cycloalkyl of 3 10 carbon atoms or an optionally substituted aryl group of 6-10 carbon atoms, or a heterocyclic group, and R3 is a free or functionally modified hydroxy group, n is 1, 2, 3, 4 or 5, and X is -CH2- or oxygen as valuable crystalline pharmaceuticals.

531395

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