Cyclodextrin complex

Details Cyclodextrin complex Cyclodextrin complex

C - Chemistry, Metallurgy

08

B

C08B 37/16 (2006.01) A61K 31/335 (2006.01) A61K 31/715 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2043253

A complex of a fumagillin derivative represented by the general formula: Image wherein R1 is hydrogen; R2 is halogen, N(O)mR5R6, N+R5R6R7 .cndot. X-, S(0)nR5 or S+R5R6 .cndot. X- (wherein R5, R6 and R7 are independently an optionally substituted hydrocarbon or heterocyclic group; X- is a counter anion; m is an integer of 0 or 1; n is an integer from 0 to 2; and R5 and R6 together with the adjacent nitrogen or sulfur atom may form a nitrogen- or sulfur-containing heterocyclic group which may be substituted and form a condensed ring); or R1 and R2 together represent a bond; R3 is 2-methyl-1-propenyl group or isobutyl group; A is 0 or NR8 (wherein R8 is hydrogen or an optionally substituted lower alkyl or aryl group); R4 is hydrogen, an optionally substituted hydrocarbon group or an optionally substituted acyl group); or a salt thereof, with an optionally etherified cyclodextrin is disclosed. The present invention also provides an antineoplastic agent containing the complex.

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