Cyclodextrin complexes

Details Cyclodextrin complexes Cyclodextrin complexes

A - Human Necessities

61

K

A61K 47/40 (2006.01) A61K 31/724 (2006.01) A61K 45/06 (2006.01) A61K 47/48 (2006.01) A61K 47/10 (2006.01) A61K 47/12 (2006.01) A61K 47/38 (2006.01)

Patent

CA 2463687

The invention provides a number of methods for enhancing the aqueous solubility of an active ingredient which is insoluble or sparingly soluble in water. In one preferred embodiment, solubilization of the active ingredient is enhanced by combining it with .beta.-cyclodextrin in an aqueous complexation medium comprising .beta.-cyclodextrin and a negatively- or positively-charged compound which forms an inclusion or non-inclusion complex with .beta.- cyclodextrin and its inclusion complexes.

L'invention concerne un certain nombre de procédés destinés à améliorer la solubilité dans l'eau d'un principe actif insoluble ou modérément soluble dans l'eau. Dans un mode de réalisation préféré, la solubilisation du principe actif est améliorée par combinaison de celui-ci avec de la .beta.-cyclodextrine dans une milieu de complexation aqueux contenant de la .beta.-cyclodextrine et un composé chargé négativement ou positivement formant un complexe d'inclusion ou de non-inclusion avec la .beta.-cyclodextrine et ses complexes d'inclusion.

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