Cyclodextrin grafted biocompatible amphiphilic polymer and...

Details Cyclodextrin grafted biocompatible amphiphilic polymer and... Cyclodextrin grafted biocompatible amphiphilic polymer and...

C - Chemistry, Metallurgy

08

B

C08B 37/16 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2468556

Amphiphilic biocompatible cyclodextrin grafted polymers comprising a hydrophobically modified cyclodextrin moiety, a linear linker and a biocompatible hydrophilic polymer backbone, wherein said cyclodextrin moiety is grafted to said biocompatible hydrophilic polymer backbone by said linker are disclosed. The cyclodextrin-grafted biocompatible polymers of this invention may be used as bioactive agent carriers. Methods of making and using such cyclodextrin-grafted biocompatible polymers are disclosed.

Ces polymères amphiphiles biocompatibles greffés avec de la cyclodextrine comportent une fraction de cyclodextrine rendue hydrophobe, un agent de liaison linéaire ainsi qu'un squelette de polymère hydrophile, la fraction de cyclodextrine étant greffée à ce squelette de polymère hydrophile au moyen de l'agent de liaison. On peut utiliser ces polymères biocompatibles greffés avec de la cyclodextrine comme véhicules d'agent bioactif. L'invention porte également sur des méthodes de production et d'utilisation de ces polymères biocompatibles greffés avec de la cyclodextrine.

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