Cyclodextrin inclusion complex of paclitaxel, and method for...

Details Cyclodextrin inclusion complex of paclitaxel, and method for... Cyclodextrin inclusion complex of paclitaxel, and method for...

C - Chemistry, Metallurgy

08

B

C08B 37/16 (2006.01) A61K 31/335 (2006.01) A61K 47/40 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2092979

There is provided a cyclodextrin or branched cyclodextrin inclusion complex of paclitaxel, a method for the production of cyclodextrin of branched cyclodextrin inclusion complex of paclitaxel characterized by adding cyclodextrin or branched cyclodextrin thereto at a molar ratio of 1-20 times with respect to paclitaxel, and a method for the improvement of the solubility of paclitaxel in water by adding cyclodextrin or branched cyclodextrin thereto at a molar ratio of 1-20 times with respect to paclitaxel. According to the present invention, the solubility of paclitaxel in water may be improved, and paclitaxel may be solubilized, by adding CD thereto at a molar ratio of 1-20 times with respect to paclitaxel. If a CD inclusion complex of paclitaxel according to the present invention is used, paclitaxel administered to cancer patients may be easily absorbed, and the physiological effects of paclitaxel may be more effectively induced.

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