C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/237, 260/305
C07D 235/02 (2006.01) A61K 31/415 (2006.01) C07D 403/10 (2006.01) C07F 9/645 (2006.01)
Patent
CA 2031916
Case 2583 Cycloheptimidazolone Compounds As Angiotensin II Antagonists for Control of Hypertension ABSTRACT A class of cycloheptimidazolone compounds is described as angiotensin II antagonists for use in control of hypertension. Compounds of particular interest are those of the formula Image wherein each of R1 and R2 is independently selected from hydrido, alkyl, halo, alkanoyl, carboxyl, alkoxycarbonyl, phenyl, haloalkyl, alkoxyalkyl, formyl, cyano, alkoxy, phenoxy, phenylthio, alkylthio; wherein R3 is alkyl,alkenyl, alkynyl, hydroxyalkyl and alkoxyalkyl; wherein each of R5 through R13 is independently selected from hydrido, alkyl, haloalkyl, halo, nitro, cyano, hydxoxy, alkoxy, alkylthio, aryl, aryloxy, arythio, and acidic groups such as carboxylic acid, with the proviso that at least one of R9 through R13 substituents is an acidic group; or a pharmaceutically-acceptable ester, amide or salt thereof.
Bovy Philippe R.
Chamberlain Timothy S.
Collins Joe T.
O'neal Joan M.
Bovy Philippe R.
Chamberlain Timothy S.
Collins Joe T.
O'neal Joan M.
Osler Hoskin & Harcourt Llp
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