C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/604.8
C07C 49/225 (2006.01) C07C 29/147 (2006.01) C07C 29/40 (2006.01) C07C 45/29 (2006.01) C07C 47/238 (2006.01)
Patent
CA 1130318
EV 4002/22 ABSTRACT A process for the manufacture of novel analgesically active cyclohexadiene derivatives (including acid addition salts) of the formula Image I wherein R1 is H or CH3, R2 is H, CH3 or C2H5, R3 is CH3 or C2H5 and R4 is H or CH3, with the proviso that at least one of R1 and R4 is H, which process comprises reacting a) biphenyl with an amine X-CHR4-C(R1)(NR2R3) or b) reacting a carbonyl compound Q-CHR4-Co(R1) under reducing conditions with an amine HNR2R3 or c) reacting a compound Q-CHR4-CH (X) (R1) with an amine HNR2R3 or d) alkylating an amine Q-CHR4-CH(R1)(NHR2) or e) reducing an amide Q-CHR4-CO-NR2R3, X being a leaving group and Q the 1-phenyl-2,5-hexadien-1-yl group, as well as the manufacture of pharmaceutical prepara- tion containing such cyclohexane derivatives.
335038
Muller Peter M.
Pfister Rudolf
Urban Rene
Gowling Lafleur Henderson Llp
Hoffmann-La Roche Limited
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