C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/215, 167/243
C07D 303/44 (2006.01) A61K 31/535 (2006.01) C07D 303/22 (2006.01) C07D 303/34 (2006.01) C07D 413/12 (2006.01)
Patent
CA 1316921
ABSTRACT The disclosure describes cyclohexane derivatives of the formula: Image (I) wherein R1 is halomethyl; or arylthiomethyl which may have amino, lower alkoxy or acylamino, R2 is lower alkoxy, or Image and R4 is hydrogen,lower alkylcarbamoyl, lower alkylcarbamoyloxy(lower)alkylcarbamoyl, heterocyclic carbonyl or heterocyclic carbamoyl, or salt thereof. These derivatives have an angio- genesis inhibitory activity. Also described are a process for the preparation of these derivatives, pharmaceutical compositions containing same.
607999
Hashimoto Masashi
Kasahara Chiyoshi
Ohkawa Takehiko
Oku Teruo
Fujisawa Pharmaceutical Co. Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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