Cyclohexane derivatives

Details Cyclohexane derivatives Cyclohexane derivatives

C - Chemistry, Metallurgy

07

C

167/179, 260/477

C07C 59/54 (2006.01) C07C 33/34 (2006.01) C07C 45/30 (2006.01) C07C 45/40 (2006.01) C07C 45/41 (2006.01) C07C 47/235 (2006.01) C07C 57/46 (2006.01) C07C 57/48 (2006.01) C07C 59/72 (2006.01) C07C 59/86 (2006.01) C07C 59/90 (2006.01) C07C 69/732 (2006.01) C07D 319/08 (2006.01)

Patent

CA 1258863

A B s T R A C T CYCLOHEXANE DERIVATIVES This invention concerns novel (4-substituted-2-phenylcyclohexyl)alkenoic and alkanoic acid derivatives of the formula I wherein one of Ra and Rb is hydrogen, hydroxy, (1-6C)alkyl, (1-6C)alkoxy, (3-6C)alkenyloxy or phenyl(1-4C)alkoxy and the other of Ra and Rb is hydrogen, (1-6C)alkyl, (1-6C)alkoxy or (3-6C)alkenyloxy; or Ra and Rb together form a (2-4C)alkylanedioxy or oxo group; benzene ring X optionally bears a substituent selected from halogeno, (1-6C)alkyl, (1-6C)alkoxy, hydroxy, (2-6C)alkanoyloxy, (1-6C)alkanoylamino, trifluoromethyl and nitro; n is 3-5; Y is ethylene or vinylene; and in the cyclohexane ring, the substituents at positions 1 and 2 have cis- or trans- relative stereochemistry; and the pharmaceutically acceptable salts, (1-6C)alkyl esters and (1-6C)alkanesulphonamides thereof. The compounds of formula I possess valuable pharmacological properties of use in medicines. The invention also concerns processes for the manufacture of, and pharmaceutical compositions containing a novel compound of formula I.

467437

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