Cyclohexane derivatives and their use as therapeutic agents

Details Cyclohexane derivatives and their use as therapeutic agents Cyclohexane derivatives and their use as therapeutic agents

C - Chemistry, Metallurgy

07

D

C07D 211/58 (2006.01) A61K 31/164 (2006.01) A61K 31/435 (2006.01) A61K 31/438 (2006.01) A61K 31/4409 (2006.01) A61K 31/495 (2006.01) A61P 1/08 (2006.01) A61P 25/04 (2006.01) A61P 25/24 (2006.01) C07C 233/31 (2006.01) C07C 233/41 (2006.01) C07C 237/10 (2006.01) C07D 211/18 (2006.01) C07D 211/44 (2006.01) C07D 241/08 (2006.01) C07D 295/12 (2006.01) C07D 295/135 (2006.01) C07D 317/72 (2006.01) C07D 401/04 (2006.01) C07D 407/04 (2006.01) C07D 471/10 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2408849

The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R17, R21a and R21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.

L'invention concerne des composés de la formule (I): où l'anneau A est un anneau phényle ou pyridyle; X représente une liaison sélectionnée dans le groupe comprenant les formules: (a), (b), (c), (d) et (e); et R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?13¿, R?14¿, R?15¿, R?16¿, R?17¿, R?21a¿ et R?21b¿ sont comme définis dans la présente invention. Ces composés s'avèrent des plus utiles dans le traitement ou la prévention des dépressions, de l'anxiété, de la douleur, des inflammations, de la migraine, des névralgies vomitives ou des algies post-zostériennes.

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