Cyclohexaneacetamide derivatives

Details Cyclohexaneacetamide derivatives Cyclohexaneacetamide derivatives

C - Chemistry, Metallurgy

07

D

167/233, 260/305

C07D 207/26 (2006.01) A61K 31/40 (2006.01) C07D 403/08 (2006.01)

Patent

CA 2007732

ABSTRACT [(5-Oxo-2-pyrrolidinyl)methyl]cyclohexaneacetamides of the formula Image I wherein R1 is hydrogen, lower alkyl or aryl-lower alkyl; R2 is hydrogen, lower alkyl, aryl, aryl-lower alkyl, Image , wherein R5 and R6 are hydrogen, lower alkyl or aryl-lower alkyl; R3 and R4, independently, are hydrogen, lower alkyl, or aryl-lower alkyl; and enantiomers, diastereomers, and racemates thereof, and, when R2 Image , pharmaceutically acceptable acid addition salts thereof exhibit cognitive enhancement and antiamnestic activity and are therefore useful, for example, in treating memory deficits associated with Alzheimer's disease or age- associated memory impairment.

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