C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/5.06, 260/55
C07K 5/06 (2006.01) A61K 31/19 (2006.01) C07C 53/134 (2006.01) C07D 303/40 (2006.01) C07F 7/18 (2006.01)
Patent
CA 1283250
ABSTRACT OF THE DISCLOSURE The present invention is directed to 2-hydroxy-4-alk- ylidenecyclohexanealkanoic acids having a mercaptoalkanoic acid substituent at the 3-position. Esters and amides corresponding to the acids referred to above are also encompassed by the present invention. These compounds are useful in the treatment of bronchial asthma and they are obtained by the reaction of an appropriate 2,3-epoxy-4- alkylidenecyclohexanealkanoate with a mercapto alkanoic acid ester in the presence of a tertiary amine. The indi- cated process gives the esters of the present invention which can be hydrolyzed to the corresponding free acids by standard procedures. The compounds described can be sub- jected to other known reactions to give the other compounds of the present invention.
516214
Cregge Robert J.
Sabol Jeffrey S.
Merrell Dow Pharmaceuticals (canada) Inc.
Osler Hoskin & Harcourt Llp
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