Cyclohexanediole derivatives

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 403/08 (2006.01) A61K 31/045 (2006.01) C07C 17/00 (2006.01) C07C 45/29 (2006.01) C07C 47/19 (2006.01) C07C 47/263 (2006.01) C07C 47/273 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2320180

Compounds of formula (I) wherein X is C=CH2 or CH2; Y and Z are independently of each other hydrogen, fluorine or hydroxy; A is -C.ident.C-, -H=CH- or -CH2-CH2-; R1 and R2 are independently of each other alkyl a perfluoroalkyl; and R3 is lower alkyl; are useful in the treatment or prevention of hyperproliferative skin diseases, particularly psoriasis, basal cell carcinomas, disorders of keratinization and keratosis; or for reversing the conditions associated with photodamage.

Les composés de la formule (I), dans laquelle X représente C=CH2 ou CH2; Y et Z représentent indépendamment l'un de l'autre hydrogène, fluor ou hydroxy, A représente -CC-, -CH=CH- ou -CH2-CH2, R<1> et R<2> représentent indépendamment l'un de l'autre alkyle ou perfluoroalkyle, et R<3> représente alkyle inférieur, sont utiles dans le traitement ou dans la prévention de maladies hyperprolifératives de la peau, notamment du psoriasis, des carcinomes basocellulaires, des troubles de la kératinisation et la kératose, ou pour s'opposer aux états associés à une photoaltération.

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