C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 317/30 (2006.01) A61K 31/166 (2006.01) A61K 31/4192 (2006.01) A61K 31/44 (2006.01) A61K 31/4412 (2006.01) A61K 31/4439 (2006.01) A61K 31/505 (2006.01) A61P 25/18 (2006.01) C07D 211/90 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 239/28 (2006.01) C07D 249/04 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2609969
The present invention provides compounds of formula I: wherein R1 is an alkyl, phenyl, heterocyclyl, cycloalkyl, alkoxy, ester, amino or amide group; R2 is a phenyl, heterocyclyl, alkyl, cycloalkyl or cycloalkylalkyl group; R3 is an alkyl, cycloalkyl, cycloalkylalkyl, amino or heterocyclyl group; R4 and R5 are hydrogen or alkyl or form a cycloalkyl ring; A is O or N; and m is zero or one; as inhibitors of GlyT1 and thus as useful for treating or preventing diseases such as schizophrenia; with the provision of pharmaceutical compositions, first and second medical uses and methods of treatment.
La présente invention concerne des composés de formule I dans laquelle R1 représente un groupe alkyle, phényle, hétérocyclyle, cycloalkyle, alcoxy, ester, amino ou amide, R2 représente un groupe phényle, hétérocyclyle, alkyle, cycloalkyle ou cycloalkylalkyle, R3représente un groupe alkyle, cycloalkyle, cycloalkylalkyle, amino ou hétérocyclyle, R4 et R5 représentent un atome d~hydrogènes ou un groupe alkyle ou forment un noyau cycloalkyle ; A représente un atome d~oxygène ou d~azote, et m vaut zéro ou un ; en tant qu'inhibiteurs de GlyT1 et par conséquent utiles pour le traiter ou la prévenir des pathologies telles que la schizophrénie, assortis de préparations pharmaceutiques, d'utilisations médicales de première et seconde intention et de procédés de traitement
Blackaby Wesley Peter
Castro Pineiro Jose Luis
Lewis Richard Thomas
Naylor Elizabeth Mary
Street Leslie Joseph
Merck Sharp & Dohme Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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