Cyclohexene carboxylates as neuraminidase inhibitors

Details Cyclohexene carboxylates as neuraminidase inhibitors Cyclohexene carboxylates as neuraminidase inhibitors

C - Chemistry, Metallurgy

07

C

C07C 233/52 (2006.01) A61K 31/215 (2006.01) C07C 69/757 (2006.01) C07C 247/14 (2006.01) C07C 271/24 (2006.01) C07D 203/26 (2006.01) C07D 303/40 (2006.01) C07D 317/46 (2006.01)

Patent

CA 2313638

Novel compounds of Formula (I) are described, R1, R2, R3, R4, R5 and R6 are described in this specification. Synthetic interme-diates and pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neu-raminidase in samples suspected of containing neuraminidase are also described. Assay methods for detecting neuraminidase activity are also described.

L'invention concerne de nouveaux composés de formule (I), dans laquelle R<1>, R<2>, R<3>, R<4>, R<5> et R<6> sont tels que spécifiés dans le descriptif. L'invention concerne également des produits intermédiaires de synthèse et des compositions pharmaceutiques renfermant les inhibiteurs de l'invention, des procédés inhibant la neuraminidase dans des échantillons susceptibles de renfermer la neuraminidase, ainsi que des procédés de criblage permettant de détecter l'activité de la neuraminidase.

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