Cyclohexyl derivatives and their use as therapeutic agents

Details Cyclohexyl derivatives and their use as therapeutic agents Cyclohexyl derivatives and their use as therapeutic agents

C - Chemistry, Metallurgy

07

D

C07D 295/16 (2006.01) A61K 31/16 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) A61K 31/495 (2006.01) A61P 1/08 (2006.01) A61P 25/04 (2006.01) A61P 25/24 (2006.01) C07C 45/29 (2006.01) C07C 49/697 (2006.01) C07C 49/747 (2006.01) C07C 49/753 (2006.01) C07C 217/52 (2006.01) C07C 233/23 (2006.01) C07C 233/31 (2006.01) C07C 233/58 (2006.01) C07C 233/59 (2006.01) C07C 235/40 (2006.01) C07C 235/82 (2006.01) C07C 237/04 (2006.01) C07C 237/06 (2006.01) C07C 237/24 (2006.01) C07D 211/48 (2006.01) C07D 211/58

Patent

CA 2410077

The present invention relates compounds of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l) and R1, R2, R3,R4, R5, R6, R7, R13, R14, R15, R16, R17, R18, R19, R21a and R21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.

La présente invention concerne des composés de formule (I), dans laquelle le cycle A est un cycle phénylique ou pyridylique, X représente un lieur choisi dans le groupe formé par (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k) et (l), et R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?13¿, R?14¿, R?15¿, R?16¿, R?17¿, R?18¿, R?19¿, R?21a¿ et R?21b¿ sont tels que définis dans cette invention. Ces composés sont notamment utilisés dans le traitement ou la prévention de la dépression, de l'anxiété, de la douleur, de l'inflammation, de la migraine, des vomissements ou de l'algie post-zostérienne.

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