Cyclohexyl prostaglandin analogs as ep4-receptor agonists

Details Cyclohexyl prostaglandin analogs as ep4-receptor agonists Cyclohexyl prostaglandin analogs as ep4-receptor agonists

A - Human Necessities

61

K

A61K 31/557 (2006.01) A61K 31/662 (2006.01) A61P 27/06 (2006.01) C07C 49/753 (2006.01) C07C 69/743 (2006.01) C07C 235/30 (2006.01) C07D 257/04 (2006.01) C07F 9/08 (2006.01)

Patent

CA 2537252

The invention relates to the use of novel cyclohexyl analogues of E-type prostaglandins as EP4 agonists, in general, and, in particular as ocular hypotensives. The cyclohexyl analogues used in accordance with the invention are represented by the following formula I wherein the wavy segments represent .alpha. or .beta. bond, dashed line represents the presence or absence of a bond W, Y, Z, R, R1 , R2 and R3 are as defined in the specification.

L'invention porte sur l'utilisation de nouveaux analogues de cyclohexyle des prostaglandines de type E comme agonistes d'EP¿4?, en général et, en particulier, comme hypotenseurs oculaires. Les analogues de cyclohexyle utilisés selon l'invention sont représentés par la formule (I) dans laquelle les segments ondulés représentent a ou une liaison .szlig., la ligne pointillée représente la présence ou l'absence d'une liaison W, Y, Z, R, R?1¿, R?2¿ et R?3¿ sont tels que définis dans la demande.

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