Cyclohexylamine derivatives as subtype selective...

Details Cyclohexylamine derivatives as subtype selective... Cyclohexylamine derivatives as subtype selective...

C - Chemistry, Metallurgy

07

D

C07D 417/10 (2006.01) A61K 31/4155 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) C07D 263/58 (2006.01) C07D 413/04 (2006.01) C07D 413/10 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2378876

-113- Described are cyclohexylamine derivatives of Formula I Image and pharmaceutically acceptable salts thereof, wherein R1, g, *, R, V, B, E, Y, G, H, X1, and d are as defined in the description. The compounds of Formulas I and VI are antagonists of NMDA receptor channel complexes useful for treating cerebral vascular disorders such as, for example, stroke, cerebral ischemia, trauma, hypoglycemia, anxiety, migraine headache, convulsions, Parkinson's disease, aminoglycoside antibiotics-induced hearing loss, psychosis, glaucoma, CMV retinitis, opioid tolerance or withdrawal; chronic pain, or urinary incontinence.

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