C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 31/4184 (2006.01) A61K 31/454 (2006.01) A61K 31/5377 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2646678
The present invention discloses novel compounds of Formula I: ( I ) having 11.beta.-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11.beta.-HSD type 1 activity.
La présente invention a pour objet de nouveaux composés de Formule I : ( I ) présentant une activité antagoniste vis-à-vis de la 11.beta.-HSD de type 1, ainsi que des méthodes de synthèse de tels composés. Dans un autre mode d'application, la présente invention concerne des compositions pharmaceutiques comprenant des composés de Formule I, ainsi que des méthodes d'utilisation des composés et des compositions dans le traitement du diabète, de l'hyperglycémie, de l'obésité, de l'hypertension, de l'hyperlipidémie, du syndrome métabolique et d'autres états pathologiques associés à l'activité de la 11.beta.-HSD de type 1.
Guenther Rebecca Lynn
Mabry Thomas Edward
Saeed Ashraf
Snyder Nancy June
Wallace Owen Brendan
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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