C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 15/00 (2006.01) C07F 13/00 (2006.01) G01N 33/52 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2745183
A complex containing a transition metal ion and a plurality of donor ligands each of which is fully coordinated to the transition metal ion and is either a nitrogen donor ligand or a cyclometalated donor ligand, such that at least one of the donor ligands is a cyclometalated donor ligand bears one or more reactive groups connected to at least one of the donor ligands through a linker that includes a chain of four or more atoms. The linker offers advantages that make the complex particularly effective in labeling biomolecules and in multiplex analyses.
Un complexe contenant un ion de métal de transition et plusieurs ligands donneurs, chacun étant entièrement coordonné à l'ion de métal de transition et étant soit un ligand donneur azoté, soit un ligand donneur cyclométallé, de sorte qu'au moins l'un des ligands donneurs soit un ligand donneur cyclométallé, porte un ou plusieurs groupements réactifs liés à au moins l'un des ligands donneurs par un pont incluant une chaîne longue de quatre atomes ou plus. Les avantages du pont rendent le complexe particulièrement efficace dans le marquage de biomolécules et les analyses multiplexées.
Bio-Rad Laboratories Inc.
Fetherstonhaugh & Co.
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