A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 45/06 (2006.01) A61K 31/195 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2461373
The invention relates to a combination which comprises (a) a cyclooxygenase-2 inhibitor ("COX-2 inhibitor") and (b) a histone deacetylase inhibitor ("HDAI") for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of pre-malignant colon lesions or a colon cancer or other malignancies in a mammal, particularly a human. The invention also relates to pharmaceutical compositions comprising such a combination and to a method of treating pre-malignant colon lesions (e.g.polyps)and colon cancer, as well as other malignancies, in a mammal, particularly a human, with such a combination. The present invention further also relates to a commercial package or product comprising such a combination.
L'invention concerne une combinaison renfermant (a) un inhibiteur de cyclooxigénase-2 ("inhibiteur de COX-2") et (b) un inhibiteur d'histone désacétylase ("inhibiteur HDAI"), aux fins d'utilisation simultanée, concurrente, séparée ou séquentielle, en particulier pour le traitement des lésions précancéreuses ou du cancer du colon chez un mammifère, et notamment chez l'être humain. L'invention concerne également des compositions pharmaceutiques contenant ladite combinaison, et un procédé qui repose sur l'utilisation de cette combinaison pour le traitement des lésions précancéreuses du colon (par exemple, polypes) et du cancer du colon, ainsi que d'autres malignités, chez un mammifère, et notamment chez l'être humain. L'invention concerne en outre un ensemble ou un produit commercial contenant la combinaison considérée.
Chen Ying-Nan Pan
Lassota Peter
Wood Alexander Wallace
Fetherstonhaugh & Co.
Novartis Ag
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