Cyclooxygenase-2 inhibitory withanolide compositions and method

Details Cyclooxygenase-2 inhibitory withanolide compositions and method Cyclooxygenase-2 inhibitory withanolide compositions and method

C - Chemistry, Metallurgy

07

J

C07J 19/00 (2006.01) A61K 31/351 (2006.01) A61K 31/366 (2006.01) A61K 31/58 (2006.01) A61K 31/704 (2006.01) A61K 31/7048 (2006.01) C07J 71/00 (2006.01)

Patent

CA 2503006

Cyclooxygenase-2 enzyme inhibiting withanolides are described. In particular, compounds from Withania somnifera are the preferred source of the withanolides, although they can be from other plant sources. The COX-2 inhibition is selective over COX-1.

L'invention concerne des withanolides inhibant l'enzyme cyclooxygénase-2. Plus particulièrement, les composés dérivés de Withania somnifera constituent la source préférée des withanolides, même s'ils peuvent être dérivés d'autres sources végétales. L'inhibition de COX-1 est sélective pour COX-1.

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