Cyclooxygenase inhibitor

Details Cyclooxygenase inhibitor Cyclooxygenase inhibitor

A - Human Necessities

61

K

A61K 31/41 (2006.01) A61K 38/00 (2006.01) A61K 38/04 (2006.01) A61K 38/06 (2006.01) A61K 38/17 (2006.01) A61K 38/38 (2006.01) A61K 45/06 (2006.01) C07C 391/02 (2006.01)

Patent

CA 2276984

A cyclooxygenase-2-inhibitor containing as an active ingredient a compound having-cyclooxygenase-2-inhibitory activity and exhibiting low toxicity that causes only minor side effects. The active compound is represented by the following formula (1) or (1'): Image wherein R1 represents a hydrogen atom or a C1-C3 alkyl group; R2 represents a hydrogen atom, a hydroxyl group, an organic group capable of being bound through its thiol group within the molecule, or R1 and R2 may loin to each other to form a single bond; R3 represents a hydrogen atom, a halogen atom, a C1-C3 alkyl group, a C1-C3 alkoxyl group, a trifluoromethyl group, or a nitro group; each of R4 and R5, which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a C1-C4 alkoxyl group, a trifluoromethyl group, or R4 and R5 may loin to each other to form a methylenedioxy group

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