Cyclopenta [d] pyrimidines as akt protein kinase inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 239/70 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2656618

The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Formula (I). Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

La présente invention concerne des composés de formule (I) et leurs tautomères, leurs énantiomères résolus, leurs diastéréomères, leurs solvates, leurs métabolites et leurs sels, ainsi que leurs promédicaments pharmaceutiquement acceptables. [Insérer formule (I)]. L'invention concerne également des procédés d'utilisation des composés de la présente invention en tant qu'inhibiteurs de la protéine kinase AKT et pour le traitement de maladies hyperprolifératives telles que le cancer.

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