Cyclopentane derivatives

Details Cyclopentane derivatives Cyclopentane derivatives

C - Chemistry, Metallurgy

07

C

260/235.01

C07C 53/50 (2006.01) A61K 9/20 (2006.01) A61K 31/19 (2006.01) A61K 31/215 (2006.01) C07C 45/63 (2006.01) C07C 45/67 (2006.01) C07C 45/68 (2006.01) C07C 53/21 (2006.01) C07C 405/00 (2006.01) C07D 307/93 (2006.01) C07D 307/935 (2006.01) C07D 309/12 (2006.01) C07F 9/143 (2006.01) C07F 9/40 (2006.01) C07F 9/50 (2006.01) C07F 9/54 (2006.01)

Patent

CA 1060888

ABSTRACT Cyclopentane derivatives of the general formula Image wherein R is hydrogen or lower alkyl; R1 is hydrogen, lower alkyl, carboxy, lower alkoxycarbonyl, hydroxymethyl, lower alkoxymethyl or the group Image ; R2 is hydroxy and R3 is hydrogen or R2 and R3 together form and oxo group; R4 is hydrogen, lower alkyl or fluoro, R5 is hydrogen or lower alkyl; and the dotted bond can be hydrogenated; with the proviso that when R4 and R5 are both hydrogen, R1 is lower alkoxycarbonyl, hydroxymethyl, lower alkoxymethyl or the group Image , and enantiomers and racemates thereof. The compounds are therapeutically active.

206171

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