Cyclopentane derivatives

Details Cyclopentane derivatives Cyclopentane derivatives

C - Chemistry, Metallurgy

07

F

260/235.01

C07F 9/54 (2006.01) C07C 405/00 (2006.01) C07D 309/12 (2006.01) C07D 317/72 (2006.01)

Patent

CA 1055488

ABSTRACT OF THE DISCLOSURE Cyclopentane derivatives of the general formula: Image (I) wherein R1 represents a hydrogen atom or a carboxylic acyl group, R represents a hydrocarbon radical optionally containing an oxygen, sulfur or halogen atom, X represents a trans-vinylene or an ethylene group, and Y is a carbonyl group or an optionally esterified carbinol group, are prepared either by the hydrolysis of corresponding compounds in which the oxo group of the cycle is replaced by an acetal group, R1 is hydrogen or a trimethylsilyl group, and Y may be a carbinol group in which the hydrogen atom of the hydroxy group is replaced by a halomagnesium group, or by the acylation of corresponding alcohols of the formula (I) in which R1 represents a hydrogen atom. These cyclopentane derivatives have been found to possess valuable pharmacological properties similar to those of "natural" prostaglandins.

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