C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/088 (2006.01) A61K 31/5375 (2006.01) A61P 1/00 (2006.01)
Patent
CA 2307661
The compounds of formula (I) are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor disorders. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.
Les composés représentés par la formule (I) sont utiles pour traiter des affections gastro-intestinales associées à des troubles de l'opposition au récepteur de motiline. Les composés sont des concurrents de l'érythromycine et de la motiline à l'égard du récepteur de motiline. De plus, les composés constituent des antagonistes de la réaction des muscles lisses contractiles à ces ligands.
Beavers Mary Pat
Chen Robert H.
Moore John B. Jr.
Xiang Min
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Ortho-Mcneil Pharmaceutical Inc.
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