C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/491, 260/353
C07C 69/732 (2006.01) C07C 43/315 (2006.01) C07D 303/40 (2006.01) C07D 309/10 (2006.01) C07D 309/12 (2006.01) C07D 317/20 (2006.01) C07D 493/08 (2006.01)
Patent
CA 2000179
This invention relates to a novel cyclopenteneheptenoic acid derivative having the following formula (see formula I) wherein R1 is hydrogen, -COCH3, -COCF3, -CO-phenyl, or a hydroxyl protecting group such as tetrahydropyranyl, tetrahydrofuranyl, or tri-lower alkylsilyl; wherein R2 is -CH2OR1, -COOH, -COOR, -CHO, -CH2-OSi(R12)3, (see formula II), (see formula III), (see formula IV), or (see formula V) wherein R is lower alkyl and each R12 is independently lower alkyl or aryl; and wherein Y is ethylene, cis-vinylene, trans-vinylene, or acetylene. Also disclosed is a novel process for preparation of the above-defined cyclopenteneheptenoic acid derivative. This process involves coupling of a higher order cuprate complex with a chiral cyclopentene compound. The resultant product is particularly useful as a starting compound for high yield synthesis of optically active prostaglandins.
Babiak Kevin A.
Campbell Arthur L.
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
LandOfFree
Cyclopenteneheptenoic acid derivatives and method of... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyclopenteneheptenoic acid derivatives and method of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclopenteneheptenoic acid derivatives and method of... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1869180