Cyclopentyl ethers and their preparation and pharmaceutical...

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A61K 31/557 (2006.01) C07C 405/00 (2006.01)

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CA 1275094

A B S T R A C T CYCLOPENTYL ETHERS AND THEIR PREPARATION AND PHARMACEUTICAL FORMULATION Compounds are described of formula (I) Image (I) in which n is 1 or 2; m is 2-5 and X is -CH=CH- or -Ch2-CH2-; or m is 1-4 and X is -CH=C=CH-; R1 is phenyl, substituted phenyl or naphthyl; Y substituted or unsubstituted 3-phenoxy- 2-hydroxypropyl. These compounds inhibit gastric acid secretion and provide gastrointestinal cytoprotection, and may be formulated for use in the treatment of ulcers.

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