Cyclopeptide derivatives

Details Cyclopeptide derivatives Cyclopeptide derivatives

C - Chemistry, Metallurgy

07

K

C07K 7/56 (2006.01) A61K 38/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2280233

Compounds of the formula (I) Cyclo-(Arg-X-Asp-R1) in which X means Gly, Ala or NH-NH-CO, R1 means a radical of formula (II), and R2, R3, and R4 have the meanings given in claim 1, and their salts, can be used as integrin inhibitors, in particular for the prevention and treatment of circulatory diseases, in cases of thrombosis, cardiac infarction, coronary heart disease, arteriosclerosis, pathological symptoms that are sustained or propagated by angiogenesis, and in tumour therapy.

Composés de formule (I) Cyclo-(Arg-X-Asp-R?1¿) dans laquelle X représente Gly, Ala ou NH-NH-CO, R?1¿ représente un reste de formule (II) et R?2¿, R?3¿ et R?4¿ sont tels que décrits dans la revendication 1, ainsi que leurs sels, qui peuvent être utilisés comme inhibiteurs de l'intégrine en particulier pour la prophylaxie et le traitement de pathologies de la circulation, en cas de thrombose, d'infarctus du myocarde, de maladies coronariennes, d'artériosclérose et de processus pathologiques favorisés ou propagés par l'angiogenèse, et pour la thérapie antitumorale.

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