Cyclopeptides

Details Cyclopeptides Cyclopeptides

C - Chemistry, Metallurgy

07

K

C07K 7/64 (2006.01) A61K 38/12 (2006.01) C07K 14/75 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2102447

The invention relates to novel cyclopeptides of the formula I cyclo-(A-B-C-D-Arg) I in which A and B are each independently of one another Ala, Asn, Asp, Arg, Cys, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Phe, Pro, Ser, Thr, Trp, Tyr or Val, C is Asp or Asp (O-C1-4-alkyl) and D is Gly or Ala, at least two of the amino acid radicals stated being present in the D-form, and their salts. These compounds act as integrin inhibitors and can be used in particular for the prophylaxis and treatment of disorders of the circulation and in tumour therapy.

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