Cyclopeptides, a method for their preparation and their use...

Details Cyclopeptides, a method for their preparation and their use... Cyclopeptides, a method for their preparation and their use...

C - Chemistry, Metallurgy

07

K

C07K 14/52 (2006.01) A61K 38/10 (2006.01) A61P 9/00 (2006.01) C07K 1/10 (2006.01) C07K 7/08 (2006.01) C07K 7/64 (2006.01) C07K 17/14 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2424506

The invention concerns cyclic peptides, the method for preparing them and their use as angiogenesis inhibitor or activator. Said cyclic peptides comprise the following peptide sequence: -Arg-Ile-Lys-Pro-Gln-Gly-. They can also be used in angiogenesis inhibiting systems comprising a support (1) whereon the cyclic peptide is fixed by an organic spacer arm (3), optionally provided with a motif (4) capable of being cleaved by an enzymatic system.

L'invention concerne des cyclopeptides, leur procédé de préparation et leur utilisation comme inhibiteur ou activateur de l'angiogenèse. Ces cyclopeptides comportent la séquence peptidique suivante: -Arg-Ile-Lys-Pro-His-Gln-Gly-Ils peuvent être utilisés dans des systèmes inhibiteurs de l'angiogenèse qui comprennent un support (1) sur lequel le cyclopeptide est fixé par l'intermédiaire d'un bras espaceur organique (3), muni éventuellement d'un motif (4) susceptible d'être coupé par un système enzymatique.

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