Cyclopeptides and pharmaceutical preparations thereof and...

Details Cyclopeptides and pharmaceutical preparations thereof and... Cyclopeptides and pharmaceutical preparations thereof and...

C - Chemistry, Metallurgy

07

K

530/7.26

C07K 14/655 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1148146

Case 4-12421/1+2/= New cyclopeptides and pharmaceutical preparations thereof and also processes for their manufacture Abstract The somatostatin-analogous cyclic octapeptides according to the invention of the general formula Image (I) in which trp represents L-Trp or D-Trp, in which the benzene ring may be substituted by a halogen atom, and Gaba(Ar) represents the residue of a .gamma.-amino- butyric acid substituted by a cyclic hydrocarbyl radical, and their acid addition salts and complexes are distin- guished by a strong inhibition of the insulin and glucagon secretion of the pancreas and are therefore therapeutically acceptable, preferably in the form of phanmaceutical preparations, in similar indications to those of somatostatin, especially as anti-diabetics. The compounds are manufactured by conventional processes of peptide synthesis, especially by liberation from corresponding protected intermediates after intramolecular cyclisation of a corresponding linear octapeptide.

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